Wine in the time of Cholera

Hey Everybody,
RJ here. And first of all I am not a doctor, nor do I play one on TV.  But I do read a lot and I apply said things to life and I have found some things that should make all wine drinkers very happy!  Turns out even scientists have been interested in the various positive properties of wine. Wine and it’s polyphenolic components (including catechin, quercetin and resveratrol) have been studied in regards to cancer, brain degeneration diseases and even cardiac care. All with scientific results that pharmaceutical companies would do anything for. Anyway the studies I want to point out today are from all around the globe. In Italy circa 2005 a study published in The Journal of Infectious Diseases tested resveratrol in vitro in mice and showed that resveratrol worked inside the infected cells to stop the DNA transcription (a process necessary for virus to multiply). The mice in the control group lived while all other infected mice not treated with wine extract died. Next is an article from 2017 by BMC Infectious Diseases that showed that resveratrol controlled MERS CoV infection in vitro. This article is “Effective inhibition of MERS CoV infection by resveratrol” by Lin, S. C. et al. It showed that resveratrol inhibits MERS CoV and other RNA viruses!  In 2019 the article "Influence of Resveratrol on the Immune Response" by L. Malaguarnera showed multiple ways resveratrol boosts people’s immune system. The conclusion was: The effects of this biologically active compound on the immune system are associated with widespread health benefits for different autoimmune and chronic inflammatory diseases. Dr Juergen Rissland, the head of Institute of Virology at Saarland University Hospital in Germany said on the Health Issues show that alcohol would help kill viruses because viruses have a fatty coating susceptible to alcohol. The journal American Journal of Epidemiology stated in the article "Intake of Wine, Beer and Spirits and the risk of Clinical Common Cold". This article said that wine consumers reduced their risk of getting the commond cold, which is caused by a virus up to 85%! Some reasons for this are:
    
    These inhibit viral infection
Active ERK1/2 signaling pathway
Enhance SIRT 1 signaling 
Down regulate FGF 2
Inhibit inflammatory cytokines by interfering with the nuclear factor - kappa B pathway
Reduce cleaved Caspase 3 levels


    These possible mechanisms for resveratrol boost immune system
Resveratrol targets SIRT 1, NF - kappa B and inflammatory cytokines
Targets adenosine monophosphate kinase
Enhances anti-oxidant enzymes
Suppresses TLR or Toll Like Receptor which causes inflammation
Suppress pro-inflmmatory genes expression


So drink good wine. To your health. Peace